BioProcess International US West
Join us in-person in San Diego or online for BioProcess International US West where Just – Evotec Biologics will be presenting.
Who’s Attending
- Cris Cable, Director Automation in Manufacturing Technical Operations at Just – Evotec Biologics
- Anna Klug, Scientist I, Cell Line Development at Just – Evotec Biologics
Presentation | 28 February from 4:30 – 5:00pm PST | Book Now
Flexible Automation to Achieve Continuous Bioprocess Manufacturing
The success of low-cost, high quality biopharmaceutical manufacturing relies on the Process Automation System, a cornerstone to Just – Evotec Biologics’ continuous manufacturing platform. This presentation will discuss the four pillars on which the automation platform was developed: (a) reconfigurability of equipment in the process train, (b) flexibility to select custom-built or commercially available process equipment, (c) management of volumes and flow control across the continuous process, and (d) custom-designing recipe sequences to drive control of the continuous unit operations. The Process Automation System supports both Hybrid (partially-connected) and End-to-End (E2E) continuous bioprocesses at up to 1000L scale, with E2E having been demonstrated at the 500L scale.
Presented by Cris Cable, Director Automation in Manufacturing Technical Operations at Just – Evotec Biologics
Presentation | 28 February from 4:30 – 5:00pm PST | Book Now
Inducible Systems for Recombinant Protein Expression in CHO Cells
To reduce the cost of recombinant protein therapeutics, significant focus has been placed on increasing cellular productivity. Higher levels of expression however increase metabolic burden and inhibit growth and cell line stability, especially if the molecule is toxic. At Just-Evotec Biologics, we have developed an inducible expression system in CHO cells to enable induction of protein expression to reduce metabolic burden and limit the effects of expressing toxic therapeutic proteins, resulting in overall higher expression.
Presented by Ana Klug, Scientist at Just – Evotec Biologics
Speakers
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Anna KlugScientist I, Cell Line DevelopmentAnna is a process development scientist in the cell line development group at Just Evotec Biologics. During her 3 years at Just, she has led the development of multiple cell lines expressing therapeutic drug candidates and contributed to the development of several internal CHO host cell lines. Additionally, Anna was an integral member in the development of the first induced pluripotent stem cell (iPSC) platform at Just for beta cell replacement therapy. Prior to joining Just, Anna received her bachelor’s degree in bioengineering from the University of Washington and researched cardiac regeneration with iPSCs.
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Cris CableDirector, Automation, Manufacturing Technical OperationsCris Cable is Director Automation in the Manufacturing Technical Operations organization at Just-Evotec Biologics, leading the Automation team responsible for the PAS and MES systems at Just. He started his career in pilot-scale cell culture process development and contributed to cell culture single-use technology development at Amgen including tech transfer support at a U.S. clinical manufacturing site as well as commercial tech transfer support at Amgen’s first dedicated single-use manufacturing plant in Singapore. Cris’ has been at Just since 2015 and was responsible for building the automation group and leading the implementation of the process automation system at the JPOD facility. Cris holds a B.S in Biology from Lewis and Clark College in Portland, OR.